How bioinformatics works for gene and genomic research would be briefly introduced to the undergraduate students who have taken courses of genetics and molecular genetics/biology (or courses equivalent to). Besides the exams of mid-term and final, we will have two mini-projects for each student to practically apply the skills taught in the classes. All the exams and mini-projects will be counted in the final score along with the in-class performance of each student.
第一週 History and Definition of Bioinformatics
第二週 Basics of Sequence Alignment and Alignment of Pairs of Sequences
第三週 Multiple Sequence Alignment
第四週 FASTA and BLAST
第五週 BLAST against Public Databases
第六週 Base Calling & Vector Masking
(mini-project 1, 15%)
第七週 Cluster Analysis for cDNA sequences
第八週 Gene Prediction: Methods and Evaluation
第九週 期中考 (30%)
第十週 EST project in livestock animals
第十一週 Introduction to Public Databases (I)
第十二週 Introduction to Public Databases (II)
第十三週 Gene Indices on TIGR
第十四週 UniGene and Locuslink on NCBI
第十五週 Metabolic and Regulatory Pathway on KEGG
(mini-project 2, 15%)
第十六週 Data Analysis for Gene Expression (I)
第十七週 Data Analysis for Gene Expression (II)
第十八週 期末考 (30%)
上課發問&回答問題 (10%)
參考書籍：
Baxevanis, A. D. and Ouellette, B. F. F. (ed.) 2001. Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins. 2nd Ed. Published by: John Wiley & Son, Inc., NY, U.S.A.
Kanehisa, M. 2000. Post-genome Informatics. Published by: Oxford University Press Inc., NY, U.S.A.
Gibson, G and S. V. Muse. 2003. 基因體科學入門(中文譯版)。編譯：曾銘仁、阮雪芬、李宗憲、吳嘉欽、陳韻如。審校：陳水田。出版：藝軒圖書出版社。